Chapter Five Quiz – Massachusetts Society for Medical Research

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Chapter Five QuizM2024-08-15T14:38:26-04:00

Course Home Chapter One Chapter Two Chapter Three Chapter Four Chapter Five Chapter Six

Chapter Five Quiz

1. Question

What are the two types of review that may be used by IACUCs?

a. Full Committee Review and Expedited Review
b. Pre-review and Full Committee review
c. Full Committee Review and Designated Member Review
d. Designated Member Review and Expedited Review

2. Question

Prior to review, what must be provided to all IACUC members?

A copy of every protocol that is due for review
b. A list of the titles of all protocols due for review
c. A presentation from the PI of each protocol due for review
d. A summary of each protocol due for review.

3. Question

Which of the following should be included in the protocol in order to secure approval and comply with regulations?

a. Relevance of the proposed study to human or animal health, the advancement of knowledge or the good of the society
b. Description of the history of the institution
c. Humane experimental endpoints and appropriate euthanasia
d. A and C

4. Question

What is the one outcome of Full Committee Review of a protocol that is not allowable when using Designated Member Review?

a. Approved
b. Not approved
c. Modifications required to secure approval
d. Veterinary review required to secure approval

5. Question

Which USDA pain category would include survival surgery that includes the use of anesthetics and analgesics?

a. Category B
b. Category C
c. Category D
d. Category E

6. Question

Which of the following would be considered a significant change that would necessitate submission and approval of a protocol amendment prior to work commencing?

a. Change in PI
b. Increase in the amount of blood being collected from a study animal
c. Change in the type of analgesia being provided post-operatively
d. All of the above

7. Question

Russell and Birch proposed the 3Rs in 1959, based upon which of the following?

a. The concept of minimizing animal exposure to pain and distress by limiting numbers and considering non-animal alternatives
b. The public’s concern about the number of animals used in research
c. The idea of completely replacing animals in research with non-animal models
d. The plan to improve scientific results by funding research using specific animal models

8. Question

When reviewing a protocol using transgenic animals, what should the IACUC consider?

a. The scientific applicability of the genetic alteration to the research proposed
b. Abnormalities that are expected or known to exist in the animals, and whether they may cause pain or distress
c. The manner in which the model addresses the scientific questions posed in the protocol
d. If using a lower order species is an appropriate replacement for transgenic animals

9. Question

What does the term “death as an endpoint” mean?

a. Ensuring that all research animals are euthanized at the end of a study
b. Painless death carried out by research personnel
c. A situation in which the unassisted death of an animal is needed as a time point in a study
d. None of the above

10. Question

What might assist a non-affiliated member in ensuring that the projects being proposed using animals are sufficiently justified?

a. Questioning the value of the project with respect to its objectives, the potential for pain or distress that the animals may experience, and the competence of the investigators and research staff to conduct the procedures being proposed
b. Asking straightforward questions about the proposed science, animal model and number of animals to be used
c. An understanding of the overall research objectives of the institution and how the proposed project addresses that mission.
d. All of the above

CHAPTER FIVE
IACUC Protocol Review – Overview
Protocol Review Process
The Animal Use Protocol
Modifications to a Protocol
Role of the Non-Affiliated Member in IACUC Protocol Review
Homework Assignment Five
Difficult Issues in Protocol Review
Chapter Five Quiz

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